Transcranial Magnetic Stimulation (TMS) is a mild form of brain stimulation that uses magnetic fields to stimulate nerve cells in the brain. It is a painless, non-invasive procedure that has been shown to be a safe and effective treatment for treatment-resistant depression. No anaesthesia is required for this treatment, and it does not cause any memory problems.

This study is taking place to find out how to achieve the best results from TMS, in terms of where it needs to be targeted on the scalp and the pattern of the magnetic pulses to use. It is thought that by doing this, the proportion of people who respond to TMS and the length of time they remain well afterwards might be increased. The area of the brain to be targeted will be identified via a MRI brain scan.